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GSE264 | mp pair pre and post treatment sample pair |
GSE265 | mp pair pre and post treatment sample pair |
GSE266 | mp pair pre and post treatment sample pair |
GSE267 | ldmtx_mp primary all cells from bone marrow aspirates taken two days after in vivo treatment with low dose methotrexate and mercaptopurine |
GSE268 | hdmtx primary all cells from bone marrow aspirates taken two days after in vivo treatment with high dose methotrexate |
GSE269 | hdmtx_mp primary all cells from bone marrow aspirates taken two days after in vivo treatment with high dose methotrexate and mercaptopurine |
GSE270 | mp primary all cells from bone marrow aspirates taken two days after in vivo treatment with mercaptopurine |
GSE271 | drosophila eye development larval stage analysis of gene expression during drosophila eye formation |
GSE272 | t and lymphocyte development profiles expression profiles of seven consecutive stages of mouse thymocyte development were generated previously known expression patterns of several genes were confirmed ten percent 304 of more than 000 of the monitored genes were found with confidence to be differentially expressed across all cell developmental stages when compared with 204 genes differentially expressed in five consecutive lineage developmental stages of bone marrow 546 genes appeared to be shared by both lineages however when four pools of functionally distinct cell stages were compared between and cell development dj rearranged precursor cells and resting immature precursor cells before and after surface ag receptor expression shared less than mature resting lymphocytes between and and only cycling precursors responding to precursor lymphocyte receptor deposition shared of these differentially expressed genes |
GSE273 | aging primary myoblasts comparison of primary myoblasts isolated from and month old dba 2jnia mice |
GSE274 | overexpression of the plant lammer kinase pk12 comparison of plants that overexpress pk12 and non transformed plants plants were grown for days under long day conditions gsm3816 gsm3819 or plants were grown for days under long day conditions gsm3820 gsm3823 hybridization was performed on arrays from arabidopsis keck resource lab array yale university containing 12k gsm3816 gsm3819 or 9k gsm3820 gsm3823 arabidopsis ests the samples corresponding to each array represent repetitions of independent biological experiments |
GSE276 | gliogenesis in drosophila in drosophila the glial cells missing gcm gene encodes transcription factor that controls the determination of glial versus neuronal fate in gcm mutants presumptive glial cells are transformed into neurons and conversely when gcm is ectopically misexpressed presumptive neurons become glia although gcm is thought to initiate glial cell development through its action on downstream genes that execute the glial differentiation program little is known about the identity of these genes to identify gcm downstream genes in comprehensive manner genome wide oligonucleotide arrays were used to analyze differential gene expression in wild type embryos versus embryos in which gcm is misexpressed throughout the neuroectoderm transcripts were analyzed at two defined temporal windows during embryogenesis this first genome wide analysis of gene expression events downstream of key developmental transcription factor presents novel level of insight into the repertoire of genes that initiate and maintain cell fate choices in cns development |
GSE277 | effect of uniconazole on wt and pkl mutant germinating seeds relative expression data from germinating seeds of columbia wt the pkl mutant pkl columbia plus uniconazole uwt and the pkl mutant plus uniconazole upkl each experimental condition wt pkl uwt and upkl has four true replicates for total of chips |
GSE278 | pancreas and islet gene expression gene expression of pancreatic exocrine cells pancreatic islets and hand selected pancreatic islets examined |
GSE279 | mammary tissue gene expression studies series of experiments to establish bovine developing mammary gland gene expression signature identify genes differentially expressed in bovine lactating mammary gland and to establish the false positive rate of the bmam microarray |
GSE280 | mouse ee uterine time course immature ovariectomized c57bl mice were treated with sesame oil vehicle or with 1 mg kg alpha ethynylestradiol ee for the length of time indicated mice received one dose except for the 3x24hr samples which received consecutive daily doses and were sacrificed 24hr after the final dose two replicates of each sample are provided in addition one time sample is included |
GSE281 | inflammatory myopathy molecular profiles of muscle tissue in patients with inflammatory myopathies |
GSE282 | interferon induction by shrna embryonic lung fibroblasts hlf infected with either control lentivirus gsm3892 or lentivirus expressing mrg15 and mrgx small hairpin rnas from the h1 poliii promoter gsm3891 the mrg15 shrna induces an interferon response that is unrelated to silencing of mrg15 |
GSE283 | sage gene rnai experiment comparisons between the salivary glands upon the rnai of sage gene vs the control |
GSE284 | skin irradiation and vitamin supplements analysis of gene expression in skin of rats subjected to electron irradiation and the effect of vitamin supplements |
GSE285 | 1hr ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE286 | 2hr ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 2hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE287 | 4hr ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 4hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE288 | 6hr ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 6hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE289 | 1hr s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE290 | 2hr s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE291 | 4hr s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE292 | 6hr s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE293 | 1hr dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE294 | 2hr dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 2hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE295 | 4hr dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 4hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE296 | 6hr dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 6hr after experimental mice received their last shock treatment all three sample treatments are identical but prepared separately |
GSE297 | 1hr s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE298 | 2hr s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE299 | 4hr s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE300 | 6hr s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted hour after the last shock treatment all three sample treatments are identical but prepared separately |
GSE301 | 1st ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr 2hr 4hr and 6hr after experimental mice received their last shock treatment |
GSE302 | 2nd ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr 2hr 4hr and 6hr after experimental mice received their last shock treatment |
GSE303 | 3rd ca1 control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr 2hr 4hr and 6hr after experimental mice received their last shock treatment |
GSE304 | 1st dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr 2hr 4hr and 6hr after experimental mice received their last shock treatment |
GSE305 | 2nd dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr 2hr 4hr and 6hr after experimental mice received their last shock treatment |
GSE306 | 3rd dg control young male c57bl 6j mice were handled by experimenter no other treatment administered rna from control mice were extracted 1hr 2hr 4hr and 6hr after experimental mice received their last shock treatment |
GSE307 | 1st s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE308 | 2nd s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE309 | 3rd s ca1 s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE310 | 1st s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE311 | 2nd s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE312 | 3rd s dg s context shock young male c57bl 6j mice were exposed to contextual fear conditioning paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals were removed to their homecage rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE313 | s ca1 shock alone young male c57bl 6j mice were placed into the novel context hours prior to receiving the training paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals remained in the training chamber for hour after the last shock rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE314 | s dg shock alone young male c57bl 6j mice were placed into the novel context hours prior to receiving the training paradigm that consisted of placement into novel spatial context for min after min sec 5 ma shock was administered through floor grid the min sec shock paradigm was repeated for total of shocks min after the last shock animals remained in the training chamber for hour after the last shock rna was extracted was extracted 1hr 2hr 4hr and 6hr after the last shock treatment |
GSE315 | sal ca1 vs mk ca1 sal saline young male c57bl 6j mice received an injection of saline microl per body weight rna from control mice were extracted 1hr 2hr 4hr and 6hr after mk experimental mice received their last shock treatment |
GSE316 | sal dg vs mk dg sal saline young male c57bl 6j mice received an injection of saline microl per body weight rna from control mice were extracted 1hr 2hr 4hr and 6hr after mk experimental mice received their last shock treatment |
GSE317 | mk ca1 vs mk s ca1 mk mk young male c57bl 6j mice received an injection of mk 300 micro per body weight rna from control mice were extracted 1hr 2hr 4hr and 6hr after mk experimental mice received their last shock treatment |
GSE318 | mk dg vs mk s dg mk mk young male c57bl 6j mice received an injection of mk 300 micro per body weight rna from control mice were extracted 1hr 2hr 4hr and 6hr after mk experimental mice received their last shock treatment |
GSE324 | bmm_c3h arc_lps_timecourse bone marrow derived macrophages bmm total rna from c3h arc mice extracted after stimulation by lps at different time points |
GSE325 | bmm_balbc_lps_timecourse bone marrow derived macrophages bmm total rna from c3h arc mice extracted after stimulation by lps at different time points |
GSE326 | bmm_c3h hej_lps_timecourse bone marrow derived macrophages bmm total rna from c3h arc mice extracted after stimulation by lps at different time points |
GSE327 | evolution of gene expression in the drosophila melanogaster subgroup little is known about broad patterns of variation and evolution of gene expression during any developmental process here we investigate variation in genome wide gene expression among drosophila simulans drosophila yakuba and four strains of drosophila melanogaster during major developmental transition the start of metamorphosis differences in gene activity between these lineages follow phylogenetic pattern and of all of the genes in these genomes differ in their developmental gene expression between at least two strains or species we identify on gene by gene basis the evolutionary forces that shape this variation and show that both within the transcriptional network that controls metamorphosis and across the whole genome the expression changes of transcription factor genes are relatively stable whereas those of their downstream targets are more likely to have evolved our results demonstrate extensive evolution of developmental gene expression among closely related species |
GSE328 | liver liver total rna catalog 1 was purchased from clontech and used as the starting material |
GSE329 | spleen spleen total rna catalog 1 was purchased from clontech and used as the starting material |
GSE330 | spleen vs liver cdna single spleen total rna catalog 1 and liver total rna catalog 1 were purchased from clontech and used as the starting material spleen was labeled with cyanine green while liver was labeled with cyanine red crna was made by the single round amplification method |
GSE331 | spleen vs liver cdna double spleen total rna catalog 1 and liver total rna catalog 1 were purchased from clontech and used as the starting material spleen was labeled with cyanine green while liver was labeled with cyanine red crna was made by the double round amplification method |
GSE332 | umrr vs spleen umrr universal mouse reference rna catalog was purchased from stratagene and used as the starting material spleen total rna catalog 1 was purchased from clontech and used as the starting material umrr was labeled with cyanine green while spleen was labeled with cyanine red crna was made by the single round amplification method |
GSE333 | umrr vs liver umrr universal mouse reference rna catalog was purchased from stratagene and used as the starting material liver total rna catalog 1 was purchased from clontech and used as the starting material umrr was labeled with cyanine green while liver was labeled with cyanine red crna was made by the single round amplification method |
GSE334 | spleen vs liver oligo single spleen total rna catalog 1 and liver total rna catalog 1 were purchased from clontech and used as the starting material spleen was labeled with cyanine green while liver was labeled with cyanine red crna was made by the single round amplification method |
GSE335 | ciprofibrate stimulated gene expression in rats samples and rna preparation |
GSE336 | hacat keratinocytes day3 vs hacat keratinocytes day10 the keratinocyte cell line hacat was cultured for three days proliferation or for ten days differentiation |
GSE337 | cdna array genes ospe hacat j10 3h 5 gy human hacat keratinocytes were cultured to confluence day10 |
GSE338 | cdna array genes nib hacat j10 3h 5 gy huamn hacat keratinocytes were cultured to confluence day10 differentiated confluent cells were irradiated at 5 gy or gy |
GSE339 | splenic dendritic cell subsets the functional relationships and properties of different sub types of dendritic cells dc remain largely undefined we used global gene profiling approach to determine gene expression patterns among murine splenic cd11c high dc subsets in an effort to better characterise these cells |
GSE340 | cocaine study the samples below represent study where gene expression levels were measured in different parts of the rat brain under cocaine treated gsm4696 gsm4698 gsm4701 and saline treated control gsm4702 gsm4706 conditions the regions studied were amygdala amy caudate putamen cpu nucleus acumbens na prefrontal cortex cpu and the ventral tegmental area vta the data were analyzed using two different computational techniques viz singular value decomposition svd and self organizing maps som to identify common set of genes that were regulated by cocaine administration |
GSE341 | bacillus_anthracis_cgh analysis of genomic content of closely related bacillus species |
GSE343 | molecular heterogeneity in acute renal allograft rejection the data set contains array lymphochip cdna array published in engl med jul 349 125 pmid title molecular heterogeneity in acute renal allograft rejection identified by dna microarray profiling background the causes and clinical course of acute rejection vary and it is not possible to predict graft outcome reliably on the basis of available clinical pathological and genetic markers we hypothesized that previously unrecognized molecular heterogeneity might underlie some of the variability in the clinical course of acute renal allograft rejection and in its response to treatment methods we used dna microarrays in systematic study of gene expression patterns in biopsy samples from normal and dysfunctional renal allografts combination of exploratory and supervised bioinformatic methods was used to analyze these profiles we found consistent differences among the gene expression patterns associated with acute rejection nephrotoxic effects of drugs chronic allograft nephropathy and normal kidneys the gene expression patterns associated with acute rejection suggested at least three possible distinct subtypes of acute rejection that although indistinguishable by light microscopy were marked by differences in immune activation and cellular proliferation since the gene expression patterns pointed to substantial variation in the composition of immune infiltrates we used immunohistochemical staining to define these subtypes further this analysis revealed striking association between dense cd20 cell infiltrates and both clinical glucocorticoid resistance 01 and graft loss 001 conclusions systematic analysis of gene expression patterns provides window on the biology and pathogenesis of renal allograft rejection biopsy samples from patients with acute rejection that are indistinguishable on conventional histologic analysis reveal extensive differences in gene expression which are associated with differences in immunologic and cellular features and clinical course the presence of dense clusters of cells in biopsy sample was strongly associated with severe graft rejection suggesting pivotal role of infiltrating cells in acute rejection |
GSE344 | spotted long oligonucleotide arrays both spotted long oligonucleotide arrays and affymetrix genechips were used to measure differential gene expression in two rna samples k562 erythroleukemia rna and the stratagene universal human reference rna |
GSE345 | ic experiment normal bladder epithelial cell explant from single normal control was treated with apf from single ic patient or mock apf two different membranes were used |
GSE346 | ic experiment normal bladder epithelial cell explants from different normal controls were treated with apf from different ic patients or mock apf from different matched controls |
GSE347 | ic experiment cells from different ic patients were run in parallel with cells from their different matched controls |
GSE348 | sage analysis of mouse brain regions sage analysis of various brain regions from to week old male c57bl mice |
GSE349 | resistant these patients proved resistant to docetaxel treatment exhibiting residual tumor of or greater remaining volume |
GSE350 | sensitive these patients were sensitive to docetaxel treatment exhibiting less than residual tumor |
GSE351 | sperm storage mechanisms in poultry turkey sperm lose viability within 18 when stored as liquid semen using current methods and extenders in contrast turkey hens maintain viable fertile sperm in their sperm storage tubules sst for or more days following single insemination our long term objectives are to identify and characterize differentially expressed genes that may underlie this prolonged sperm storage and then use this information to develop improved methods for storing liquid turkey semen we employed serial analysis of gene expression sage to compare gene expression patterns in turkey sst recovered from hens after artificial insemination ai with extended semen sperm ai or extender alone control ai we constructed two separate sage libraries with sst rna obtained from sperm and control ai hens we used these libraries to generate 325 ten base pair sage tags these 325 tags represented 430 unique genes the sperm and control ai libraries contained 663 and 662 tags representing 030 and 101 putative unique transcripts respectively approximately of these putative unique genes were differentially expressed 05 between treatments tentative annotations were ascribed to the sage tag nucleotide sequences by comparing them against publicly available sage tag and cdna sequence databases based on its sage tag nucleotide sequence we cloned partial turkey avidin cdna and confirmed its up regulation in the sperm ai sst the bioinformatics and experimental procedures employed to clone turkey avidin and confirm its differential expression represent useful paradigm for analyzing sage tag data from relatively uncharacterized model systems |
GSE352 | cerebellum of lurcher lc mouse analysis of gene expression in cerebellum of postnatal day lurcher lc mouse compared to wild type littermate |
GSE353 | effect of age on skeletal muscle comparison of gene expression in young soleus muscle 4 months with old soleus muscle 31 months |
GSE354 | cdna array genes ospe hacat j10 24h 5 gy human keratinocytes were cultured to confluence day differentiated confluent cells were irradiated at 5 and gy rna from irradiated cells was compared to rna from non irradiated reference cells in dye swap procedure after irradiation |
GSE356 | cdna array genes nib hacat j10 24h 5 gy human hacat keratinocytes were cultured to confluence day10 differentiated confluent cells were irradiated at 5 gy or gy |
GSE357 | halothane repetitive exposure controls 5 exposures 10 exposures rats were exposed to minutes of 8 halothane twice day for total of or exposures animals did not require intubation all exposures and hybridizations were performed at the univ of pennsylvania |
GSE358 | isoflurane repetitive exposure controls 5 exposures 10 exposures rats were exposed to minutes of 0 isoflurane twice day for total of or exposures animals did not require intubation all exposures and hybridizations were performed at the univ of pennsylvania |
GSE359 | isoflurane single exposures controls 1 hr exposure and 2 hr exposure rna extractions and microarray hybridization were performed at the university of of california davis male sprague dawley rats were used in this study and were intubated during the exposures |
GSE360 | macrophages and dendritic cells exposed to phylogenetically distinct parasites monocyte derived dendritic cells dc and macrophages mφ generated in vitro from the same individual blood donors were exposed to five different pathogens and gene expression profiles were assessed by microarray analysis responses to mycobacterium tuberculosis and to phylogenetically distinct protozoan leishmania major donovani toxoplasma gondii and helminth brugia malayi parasites were examined each of which produces chronic infections in humans yet vary considerably in the nature of the immune responses they trigger |
GSE361 | mammary epithelial cell transduction analysis of gene expression in mammary epithelial cells transduced with either htert empty lxsn vector or empty babe vector |
GSE362 | normal human muscle u133 arrays vastus lateralis biopsies were obtained from healthy subjects either young adults 29 yr old or older 75 yr old |
GSE363 | diet induced changes in mouse liver examination of gene expression profiles from liver of c57bl mice and ldl receptor deficient mice fed on either low fat diet or high fat western style diet for weeks three replicates of each condition analyzed |
GSE364 | molecular profiling of human hepatocarcinogenesis comparison of hepatocellular carcinoma with non cancerous liver tissue |
GSE365 | dna repair in mycobacterium tuberculosis molecular analysis of dna repair mechanisms in mycobacterium tuberculosis bacteria exposed to mitomycin uv irradiation or hydrogen perxoxide treatment for up to hours |
GSE366 | somatic cells in testes gene expression profiles of somatic cells of fetal and adult testis |
GSE367 | hypothalamus response to lps and restraint stress the paraventricular hypothalamic nucleus pvh is key site for integrating neuroendocrine autonomic and behavioral adjustments to diverse homeostatic challenges including physiological g infection or hemorrhage and emotional g restraint rst or footshock stresses both types of challenges ultimately converge to activate common response systems represented in pvh including the hypothalamo pituitary adrenal axis and the sympathoadrenal system oligonucleotide microarrays u74a affymetrix santa clara ca were used to compare and contrast gene expression profiles in the pvh elicited at and hr after acute exposure to representative physiological intraperitoneal injection of microg lipopolysaccharide lps and emotional min rst stressors in general the two challenges recruited relatively few genes in common with the degree of overlap varying across functional classes of genes the greatest degree of commonality was seen among signaling molecules and neuropeptides whereas transcription factors upregulated by rst and lps were largely distinct unexpectedly rst induced number of immune related molecules which were not regulated by lps hybridization histochemical analyses localized subset of responsive transcripts to the pvh and or immediately adjoining regions immunerelated molecules in particular distributed broadly to vascular and other barrier associated cell types these global transcriptional profiles inform the search for early transcription factors and late target genes mechanisms in the modulation of pvh and generalized cns responses to categorically distinct stressors |
GSE369 | ifng and conditional socs3 mice cytokine treatments changes in mouse liver mrna profiles following intraperitoneal cytokine injection |
GSE370 | spleen vs methyl thio atp treated cell total rna from mouse male c57bl spleen labeled with cy3 vs total rna from mouse male c57bl cells treated with methyl thio atp labeled with cy5 time course with repeats |
GSE371 | spleen vs anti igm treated cell total rna from mouse male c57bl spleen labeled with cy3 vs total rna from mouse male c57bl cells treated with anti igm labeled with cy5 time course with repeats |
GSE372 | spleen vs baff treated cell total rna from mouse male c57bl spleen labeled with cy3 vs total rna from mouse male c57bl cells treated with baff labeled with cy5 time course with repeats |